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Sir is an honorific address used in a number of situations in many anglophone cultures. The term can be used as a formal prefix, especially in the Commonwealth , for males who have been given certain honours or titles (such as knights and baronets ), where usage is strictly governed by law and custom.
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SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 ( S. cerevisiae ) , referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity). 
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